06-11-2022, 11:38 AM
1) Cafeína trataría de evitar. Yo soy fanático del café (no tomo en exceso pero siempre uno o dos filtrados por día) pero el día que vaya a tomar MDMA no tomo café. Hay evidencia de que potencia la neurotoxicidad en ratas.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3492978/
2) Creería que no te va a interferir mucho el pegue ese almuerzo. No parece ni mucha cantidad ni muy lento de digerir.
3) No tengo información al respecto pero no se me hace que debería haber problema con el multivitamínico. En lo posible tratá de espaciarlo unas 3 horas de la toma de MDMA.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3492978/
Cita:Concomitant consumption of caffeine with recreational psychostimulant drugs of abuse can provoke severe acute adverse reactions in addition to longer term consequences. The mechanisms by which caffeine increases the toxicity of psychostimulants include changes in body temperature regulation, cardiotoxicity and lowering of the seizure threshold. Caffeine also influences the stimulatory, discriminative and reinforcing effects of psychostimulant drugs. In this review, we consider our current understanding of such caffeine-related drug interactions, placing a particular emphasis on an adverse interaction between caffeine and the substituted amphetamine, 3,4-methylenedioxymethamphetamine (MDMA, ‘ecstasy’), which has been most recently described and characterized. Co-administration of caffeine profoundly enhances the acute toxicity of MDMA in rats, as manifested by high core body temperature, tachycardia and increased mortality. In addition, co-administration of caffeine enhances the long-term serotonergic neurotoxicity induced by MDMA. Observations to date support an interactive model of drug-induced toxicity comprising MDMA-related enhancement of dopamine release coupled to a caffeine-mediated antagonism of adenosine receptors in addition to inhibition of PDE. These experiments are reviewed together with reports of caffeine-related drug interactions with cocaine, d-amphetamine and ephedrine where similar mechanisms are implicated. Understanding the underlying mechanisms will guide appropriate intervention strategies for the management of severe reactions and potential for increased drug-related toxicity, resulting from concomitant caffeine consumption.
2) Creería que no te va a interferir mucho el pegue ese almuerzo. No parece ni mucha cantidad ni muy lento de digerir.
3) No tengo información al respecto pero no se me hace que debería haber problema con el multivitamínico. En lo posible tratá de espaciarlo unas 3 horas de la toma de MDMA.
